Hereditary Cancer Risk Assessment
It is estimated that 5%-10% of all cancer cases are caused by genetic mutations that we have since birth (Hereditary Cancer).
DrGene's Hereditary Cancer Risk Assessment searches for gene variants linked to some of the most common cancers.
For women, these include breast cancer, which is responsible for over 25% of all cancer cases, and colorectal and thyroid cancers, which together account for a further 19% of cases.
The test is equally important for men, covering three of the most common cancers: colorectal, prostate and stomach cancer. Together, these account for around 34% of cancer cases among Asian men.
In the event a mutation is found, you and your physician can plan early detection and treatment to more effectively beat cancer. Early detection is the best strategy for defeating cancer today.
 
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Service Details
Helping you to manage your health with confidence
Search your DNA for genetic variants that are linked to an increased risk of cancer.
  • Checks for genetic variations linked to many cancers, including breast, prostate and colon cancers.
  • Genes selected by a panel of leading experts in the field of cancer genetics.
  • Most comprehensive with full sequencing of over 70 genes
One simple test, a world of information
There are over 200 different types of cancer. However just four types account for more than 50% of cancer cases: breast, prostate, colorectal and lung. In Asia, more than 25% of cases of cancer in women are breast cancer.
Many forms of cancer can be hereditary: the risk of developing the disease is linked to a genetic mutation passed from parent to child. DrGene's Hereditary Cancer Risk Assessment examines over 70 genes that are strongly linked to the risk of developing many different cancers, including breast cancer, prostate cancer and colorectal cancer.
Peace of mind
For many types of cancer, early detection can greatly improve the chance of a good outcome.
DrGene's Hereditary Cancer Risk Assessment identifies genetic variations that are linked to a higher risk of certain cancers. If your DrGene results show that you have any of these variations, your doctor will discuss this with you and may recommend regular monitoring to give you the best chance of early detection.
For patients already with cancer, the test can assist your oncologist with detecting the exact cause of the cancer, and can affect the course of treatment and type of medication used.
Is this package right for me?
DrGene's Hereditary Cancer Risk Assessment is recommended to anyone with a family history of hereditary cancer.
Genes Detected in the test:
AKT1, APC, AR, ATM, ATR, AXIN2, BAP1, BARD1, BLM, BMPR1A, BRCA1, BRCA2, BRIP1, BTK, CDC73, CDH1, CDK4, CDKN2A, CHEK2, DICER1, EPCAM, FANCC, GALNT12, GREM1, HOXB13, KIT, MEN1, MET, MLH1, MRE11A, MSH2, MSH6, MUTYH, NBN, NF1, NF2, PALB2, PALLD, PDGFRA, PIK3CA, PMS1, PMS2, POLD1, POLH, PRKAR1A, PRSS1, PTCH1, PTEN, RAD50, RAD51, RAD51C, RAD51D , RB1, RBBP8, RET, SDHA, SDHAF2, SDHB, SDHC, SDHD, SMAD4, SMARCA4, SPINK1, STK11, TP53, TP53BP1, TSC1, TSC2, VHL, WT1, XRCC2, XRCC3.
Examples of common Syndromes the test covers
Syndrome (Genes)Related Cancer Types
  • Hereditary breast cancer and ovarian cancer syndrome
    (BRCA1 and BRCA2, as well as AKT1, BAP1, BARD1, BRIP1, PALB2, PIK3CA, RAD50, RAD51, RAD51C, TP53, TP53BP1, XRCC2, XRCC3)
    Female breast and ovarian cancers; other cancers including prostate, pancreatic and male breast cancer.
  • Li-Fraumeni syndrome
    (TP53, CHEK2)
    Breast cancer, soft tissue sarcoma, osteosarcoma (bone cancer), leukaemia, brain tumours, adrenocortical carcinoma (cancer of the adrenal glands) and other cancers.
  • Lynch syndrome (hereditary nonpolyposis colorectal cancer)
    (MSH2, MLH1, MSH6)
    Colorectal, endometrial, ovarian, renal pelvis, pancreatic, small intestine, liver and biliary tract, stomach, brain, and breast cancers.
  • Familial adenomatous polyposis
    (APC)
    Colorectal cancer, multiple non-malignant colon polyps, and both non-cancerous (benign) and cancerous tumours in the small intestine, brain, stomach, bone, skin and other tissues.
  • MYH-associated polyposis
    (MYH (MUTYH))
    Multiple adenomatous colon polyps (colorectal cancer).
  • Peutz-Jeghers Syndrome
    (STK11)
    Hamartomatous polyps in the digestive tract: cancers of the breast, colon, pancreas, stomach, ovaries and other types.
  • Von Hippel-Lindau syndrome
    (VHL)
    Kidney cancer and multiple noncancerous tumours, including pheochromocytoma.
  • Multiple Endocrine Neoplasia Type 1 (Wermer syndrome)
    (MEN1)
    Pancreatic endocrine tumours and tumours of the endocrine (hormone producing) glands: parathyroid gland, islet cells of the pancreas, and pituitary glands. Other endocrine tumours include adrenal cortical tumours and carcinoid tumours, as well as tumours in other parts of the digestive tract.
  • Multiple endocrine neoplasia type 2
    (RET)
    Medullary thyroid cancer and pheochromocytoma (benign adrenal gland tumour)
  • Neurofibromatosis type 1
    (NF1)
    Neurofibromas, benign eye tumours (Lisch nodules growing on the iris of the eye) and cancerous eye tumours (glioma growing in the optic nerve), brain tumours , adrenal gland tumours, muscle tumours, spinal cord tumours, malignant peripheral nerve sheath tumours